Top 10 Hotels in Santa Fe, FL (from $61) 2026 - Competitive Prices

Upfront pricing
Our total price for your stay includes taxes and fees
Treat yourself
Save 10% or more on over 100,000 hotels worldwide with Member Prices
Learn about One Key
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Santa Fe

Pet friendly

Apartment

Condo

Hot tub

Pool

Cottage

Family friendly

Cabin

Waterpark

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Santa Fe hotels

A modern kitchen area with a central counter, various food stations, and a chalkboard menu.

A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

A hotel room with two beds, a desk, a chair, a TV, and a couch.

1. Hampton Inn & Suites Alachua I-75

Alachua

Pamela

$110 nightly

$123 total

Nov 2 - Nov 3

Total with taxes and fees

A spacious indoor dining area with multiple tables and chairs, large windows offering a view of palm trees and greenery outside.

A modern office space with a reception desk, several chairs, a large window, and a colorful abstract painting on the wall.

A Holiday Inn Express & Suites hotel with a modern design, multiple floors, and a parking lot.

A lobby with a patterned carpet, two green armchairs, a white sofa, a small round table with a plant, and framed artwork on the wall.

2. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

Harold

$111 nightly

$125 total

Oct 25 - Oct 26

Total with taxes and fees

A large, multi-story hotel with a central courtyard, palm trees, and an American flag.

A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.

A bar area with wooden chairs, a bar counter, and a television mounted on the wall.

A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

3. Best Western Gateway Grand

Gainesville

Jason

$93 nightly

$104 total

Oct 18 - Oct 19

Total with taxes and fees

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

A modern kitchen with blue-tiled walls, stainless steel appliances, and a central island.

A modern lounge area with a flat-screen TV, a fireplace, teal and brown seating, patterned carpet, and a wall-mounted clock.

A hotel reception area with directional signs for elevators, floor 1, pool restrooms, and business center.

4. La Quinta by Wyndham Gainesville

Gainesville

Elizabeth

$99 nightly

$111 total

Oct 18 - Oct 19

Total with taxes and fees

A cozy restaurant with wooden beams, yellow walls, and a bar area with coffee machines.

A reception desk with a sign reading "Quality by Choice Hotels," surrounded by various reptile decorations.

A hotel room with a bed, a desk with a chair, a television, a mirror, and a wardrobe.

A swimming pool with lounge chairs and umbrellas, a covered seating area, and a multi-story building with balconies.

5. Quality Inn Alachua - Gainesville Area

Alachua

Deborah

$76 nightly

$85 total

Nov 4 - Nov 5

Total with taxes and fees

A stone water feature with cascading water, surrounded by a brick wall and greenery.

A spacious living area with a wooden floor, a blue sofa, a round coffee table, and a ceiling fan.

A reception desk with a modern design, a ceiling fan, and a seating area with chairs and a table.

A neatly arranged bedroom with a bed, bedside lamps, a TV, and a mirror.

6. BlueGem Motel

High Springs

Wesley

$92 nightly

$104 total

Oct 18 - Oct 19

Total with taxes and fees

A modern hotel room with a large bed, a desk, a chair, and a TV.

A motel with a covered entrance, multiple parking spaces, and a fire extinguisher on the wall.

A workspace with two chairs, a desk, a computer monitor, and a wall-mounted sign reading 'BUSINESS CENTER'.

A gym with treadmills, exercise balls, and dumbbells.

7. Clarion Pointe Alachua - Gainesville Area

Alachua

María Teresa

$63 nightly

$71 total

Oct 22 - Oct 23

Total with taxes and fees

A hotel room with a bed, bedside tables, a desk, a chair, a mirror, and a window.

A reception area with a counter, a computer, and a bulletin board with pamphlets.

A corner room with two checkered chairs, a small table, a framed picture on the wall, and a floor lamp.

A bathroom with a large mirror, a sink, and a towel rack.

8. Palms Garden Inn

Lake City

Igor

$68 nightly

$77 total

Nov 13 - Nov 14

Total with taxes and fees

A spacious hotel lobby with a checkered carpet, wooden paneling, and two large chandeliers.

A hotel room with a sofa, a desk, a chair, a bed, a TV, and a dining table with a glass and cookie.

A modern gym with treadmills, exercise bikes, and weight equipment.

9. Hotel Indigo Gainesville-Celebration Pointe by IHG

Gainesville

Arleana

$102 nightly

$115 total

Oct 18 - Oct 19

Total with taxes and fees

A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.

A modern kitchen with wooden cabinets, a granite countertop, and pendant lighting.

A hotel lobby with a stone wall, a flat-screen TV, orange upholstered seating, and a lamp.

A hotel room with two beds, a large headboard, bedside lamps, and a view of the outdoors through sheer curtains.

10. Drury Inn & Suites Gainesville

Gainesville

Adam

$106 nightly

$119 total

Oct 19 - Oct 20

Total with taxes and fees

A multi-story hotel with a central entrance, palm trees, and a clear sky.

A modern living room with a green sofa, a round coffee table, and a fireplace.

A hotel room with a wooden floor, a red armchair, a beige sofa, a TV, and framed artwork on the wall.

A hotel room with a bed, a desk, a television, a sofa, and artwork on the wall.

11. Country Inn & Suites by Radisson, Gainesville, FL

Gainesville

sherry

$88 nightly

$99 total

Oct 25 - Oct 26

Total with taxes and fees

A modern breakfast area with labeled dispensers for yogurt, eggs, and milk, a coffee machine, and a chalkboard menu.

A hotel room with two beds, a TV, a desk, and a chair.

A Holiday Inn Express building with a modern design, featuring multiple windows and a flat roof.

A modern reception desk area with a blue geometric wall design, wooden accents, and a visible reception counter.

12. Holiday Inn Express Starke by IHG

Starke

Judy

$110 nightly

$122 total

Oct 18 - Oct 19

Total with taxes and fees

A swimming pool with a metal ladder, surrounded by a white fence and green chairs.

A hotel room with a patterned carpet, a sofa, a small table, a lamp, and a door with a notice.

A living room with a curved sofa, a wooden cabinet, and a fish tank.

A hotel room with a bed, a sofa, a coffee table, and a small table with a lamp.

13. Best Western Waldo Inn and Suites

Waldo

Christine

$84 nightly

$95 total

Oct 22 - Oct 23

Total with taxes and fees

A cabin with a cozy interior, a dining area, and a view of the forest.

A bedroom with a wooden headboard, a bed with white linens, a window with a view of green foliage, and a tray with breakfast items.

A cozy cabin interior with a wooden interior, a dining table with a chair, a window, and a hanging lantern.

14. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

High Springs

$209 nightly

$230 total

Oct 26 - Oct 27

Total with taxes and fees

A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.

A small building with a green roof, a covered porch with wicker chairs, and a table.

A bedroom with a bed, a chair, a dresser, a ceiling fan, a window with blinds, and a wall-mounted air conditioner.

A stone outdoor seating area with a table and benches, a trash bin, and a building in the background.

15. High Springs Country Inn

High Springs

Luis

$73 nightly

$82 total

Nov 12 - Nov 13

Total with taxes and fees

A hotel room with two beds, a desk, a chair, and a television.

A parking lot with marked lanes and a grassy area on one side.

A bathroom with a white sink, mirror, and towel rack.

A motel with a two-story structure, a covered front entrance, and a parking lot with several cars.

16. Royal Inn

Alachua

James

$61 nightly

$69 total

Oct 15 - Oct 16

Total with taxes and fees

A modern bar area with wooden bar stools, pendant lighting, and artwork on the walls.

A hotel reception desk with a wooden panel design, a digital kiosk, and a "Welcome to the Sun Shine State" sign.

A hotel hallway with carpeted floors, doors on both sides, and overhead lighting.

A hotel room with a living area, kitchenette, and a large mirror.

17. Hampton Inn Gainesville

Gainesville

Ross

$95 nightly

$107 total

Oct 18 - Oct 19

Total with taxes and fees

An outdoor patio with wicker furniture, stone walls, and a barbecue grill.

A modern living room with a sectional sofa, a standing lamp, a large window with sheer curtains, a flat-screen TV, and a built-in air conditioning unit.

TownePlace Suites Marriott with a modern exterior, multiple windows, and a covered entrance area.

A modern dining area with a wooden table, blue upholstered chairs, and pendant lighting.

18. TownePlace Suites by Marriott Gainesville Northwest

Gainesville

Tanya

$105 nightly

$118 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel room with a bed, two bedside tables with lamps, a large bathtub, and green walls.

A Sleep Inn & Suites building with a clear entrance, a covered waiting area, and a parking lot.

A breakfast bar with a juice dispenser, cereal boxes, and fruit bowls.

Outdoor lounge chairs with metal frames and fabric seats, arranged in rows.

19. Sleep Inn & Suites University/Shands

Gainesville

Diego

$85 nightly

$96 total

Nov 4 - Nov 5

Total with taxes and fees

A modern kitchen with a flat-screen TV, a microwave, and a coffee maker on a wooden cabinet. There is a window with a view of a green landscape.

A narrow kitchen with a wooden ceiling, a green refrigerator, and a wooden countertop.

A kitchen with a green refrigerator, a wooden countertop, a black kettle, and a wooden cutting board.

20. Vista Verde Farm Retreat

Lake City

Stacy

$181 nightly

$203 total

Oct 18 - Oct 19

Total with taxes and fees

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Santa Fe Hotel Reviews

Hotel Indigo Gainesville-Celebration Pointe by IHG

10/10 Excellent

"L"

Comfort Suites Gainesville near University

10/10 Excellent

"Absolutely clean and comfortable...💪💪💪💪"

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Great place to stay for checking out the springs in the area"

Red Roof Inn PLUS+ Gainesville

10/10 Excellent

"Excellent location near Restaurants and fast foods"

Best Western Gateway Grand

8/10 Good

"We enjoyed our stay"

DoubleTree by Hilton Gainesville

8/10 Good

"Clean and convenient location"

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"Staff was friendly and helpful. Breakfast was good."

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

3500 Southwest 42nd St Gainesville FL

$54 nightly

$61 total

Oct 25 - Oct 26

Total with taxes and fees

7.4/10 Good! (1,322 reviews)

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL

$72 nightly

$81 total

Oct 15 - Oct 16

Total with taxes and fees

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL

$77 nightly

$87 total

Oct 21 - Oct 22

Total with taxes and fees

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL

$84 nightly

$95 total

Oct 25 - Oct 26

Total with taxes and fees

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL

$85 nightly

$96 total

Nov 4 - Nov 5

Total with taxes and fees

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL

$85 nightly

$96 total

Nov 8 - Nov 9

Total with taxes and fees

9/10 Wonderful! (1,534 reviews)

Hotels in Santa Fe with star-rating

Frequently asked questions

What's the best place for a stay in Santa Fe?

Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Sleep Inn & Suites University/Shands and Country Inn & Suites by Radisson, Gainesville, FL. See all available top hotels, or vacation rentals in Santa Fe.

What are some of the best vacation rentals in Santa Fe?

5BR UF Family Retreat with Private Pool, Pond, Game Room – Sleeps 10: This vacation home rental outside of Santa Fe is located on a lake and has an outdoor pool, a fireplace, and a barbecue grill to put you at ease in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. It offers a patio, a garden, and a selection of games so you can immerse yourself in your vacation. See all vacation rentals in Santa Fe.

If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.

Where can I learn more about changing or cancelling my trip to Santa Fe?

To access more information about picking new dates or cancelling your trip to Santa Fe, go to https://www.expedia.com/service/.

What is staying in Santa Fe like?

Travelers to Santa Fe will find plenty to explore and enjoy. There are 796 hotels and other accommodations in the surrounding area. Find out more about Santa Fe.

What are the top places to visit in Santa Fe?

Places to visit in the wider area include Turkey Creek Golf Course, O'Leno State Park, and San Felasco Hammock Preserve State Park. You'll also find Devil's Milhopper Geological State Park and Gainesville Raceway in the area. Check out what more to see and do in Expedia's Santa Fe guide.

What's the seasonal weather like in Santa Fe?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. The rainiest months in Santa Fe are August, June, July, and September, with each month seeing an average of 7 inches of rainfall.

Explore a world of travel with Expedia

Things to do in High Springs

Find hotels in Santa Fe, FL from $61

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Santa Fe

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Fe hotels

1. Hampton Inn & Suites Alachua I-75

2. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3. Best Western Gateway Grand

4. La Quinta by Wyndham Gainesville

5. Quality Inn Alachua - Gainesville Area

6. BlueGem Motel

7. Clarion Pointe Alachua - Gainesville Area

8. Palms Garden Inn

9. Hotel Indigo Gainesville-Celebration Pointe by IHG

10. Drury Inn & Suites Gainesville

11. Country Inn & Suites by Radisson, Gainesville, FL

12. Holiday Inn Express Starke by IHG

13. Best Western Waldo Inn and Suites

14. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

15. High Springs Country Inn

16. Royal Inn

17. Hampton Inn Gainesville

18. TownePlace Suites by Marriott Gainesville Northwest

19. Sleep Inn & Suites University/Shands

20. Vista Verde Farm Retreat

Top Santa Fe Hotel Reviews

Hotel Indigo Gainesville-Celebration Pointe by IHG

Comfort Suites Gainesville near University

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Red Roof Inn PLUS+ Gainesville

Best Western Gateway Grand

DoubleTree by Hilton Gainesville

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

Days Inn by Wyndham Gainesville University I-75

HOM Hotel Gainesville, SureStay Collection by Best Western

Comfort Inn Gainesville - University Area

Sleep Inn & Suites University/Shands

Comfort Suites Gainesville near University

Hotels in Santa Fe with star-rating

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app